Influence of nimodipine, verapamil and lanthanum on histamine release from human basophils: effect of pretreatment with sialidase

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Standard

Influence of nimodipine, verapamil and lanthanum on histamine release from human basophils : effect of pretreatment with sialidase. / Jensen, C B; Thastrup, Ole; Norn, S; Skov, P S.

I: Pharmacology & Toxicology, Bind 60, Nr. 3, 1987, s. 214-6.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Jensen, CB, Thastrup, O, Norn, S & Skov, PS 1987, 'Influence of nimodipine, verapamil and lanthanum on histamine release from human basophils: effect of pretreatment with sialidase', Pharmacology & Toxicology, bind 60, nr. 3, s. 214-6.

APA

Jensen, C. B., Thastrup, O., Norn, S., & Skov, P. S. (1987). Influence of nimodipine, verapamil and lanthanum on histamine release from human basophils: effect of pretreatment with sialidase. Pharmacology & Toxicology, 60(3), 214-6.

Vancouver

Jensen CB, Thastrup O, Norn S, Skov PS. Influence of nimodipine, verapamil and lanthanum on histamine release from human basophils: effect of pretreatment with sialidase. Pharmacology & Toxicology. 1987;60(3):214-6.

Author

Jensen, C B ; Thastrup, Ole ; Norn, S ; Skov, P S. / Influence of nimodipine, verapamil and lanthanum on histamine release from human basophils : effect of pretreatment with sialidase. I: Pharmacology & Toxicology. 1987 ; Bind 60, Nr. 3. s. 214-6.

Bibtex

@article{136fc614680b4c3ea39b9275ea4010d7,
title = "Influence of nimodipine, verapamil and lanthanum on histamine release from human basophils: effect of pretreatment with sialidase",
abstract = "Our previous studies suggest that the membrane content of sialic acid influences histamine release from human basophils by interfering with the transmembraneous calcium fluxes preceding histamine release. In this study we investigated a possible interaction between membrane sialic acid and the calcium channels, using the calcium antagonists nimodipine, verapamil and lanthanum. Anti-IgE-induced histamine release was inhibited by verapamil, nimodipine and lanthanum. When cells were pretreated with sialidase in order to remove sialic acid from the cell membrane, the inhibitory action of nimodipine was abolished, whereas the inhibition by verapamil or lanthanum was unaffected. This difference may be explained by the different mode of action of the calcium channel antagonists, and the results suggest an association between membrane sialic acid and the calcium channel.",
keywords = "Basophils, Cell Membrane, Histamine Release, Humans, Lanthanum, Neuraminidase, Nimodipine, Sialic Acids, Verapamil",
author = "Jensen, {C B} and Ole Thastrup and S Norn and Skov, {P S}",
year = "1987",
language = "English",
volume = "60",
pages = "214--6",
journal = "Pharmacology and Toxicology",
issn = "0901-9928",
publisher = "Munksgaard ",
number = "3",

}

RIS

TY - JOUR

T1 - Influence of nimodipine, verapamil and lanthanum on histamine release from human basophils

T2 - effect of pretreatment with sialidase

AU - Jensen, C B

AU - Thastrup, Ole

AU - Norn, S

AU - Skov, P S

PY - 1987

Y1 - 1987

N2 - Our previous studies suggest that the membrane content of sialic acid influences histamine release from human basophils by interfering with the transmembraneous calcium fluxes preceding histamine release. In this study we investigated a possible interaction between membrane sialic acid and the calcium channels, using the calcium antagonists nimodipine, verapamil and lanthanum. Anti-IgE-induced histamine release was inhibited by verapamil, nimodipine and lanthanum. When cells were pretreated with sialidase in order to remove sialic acid from the cell membrane, the inhibitory action of nimodipine was abolished, whereas the inhibition by verapamil or lanthanum was unaffected. This difference may be explained by the different mode of action of the calcium channel antagonists, and the results suggest an association between membrane sialic acid and the calcium channel.

AB - Our previous studies suggest that the membrane content of sialic acid influences histamine release from human basophils by interfering with the transmembraneous calcium fluxes preceding histamine release. In this study we investigated a possible interaction between membrane sialic acid and the calcium channels, using the calcium antagonists nimodipine, verapamil and lanthanum. Anti-IgE-induced histamine release was inhibited by verapamil, nimodipine and lanthanum. When cells were pretreated with sialidase in order to remove sialic acid from the cell membrane, the inhibitory action of nimodipine was abolished, whereas the inhibition by verapamil or lanthanum was unaffected. This difference may be explained by the different mode of action of the calcium channel antagonists, and the results suggest an association between membrane sialic acid and the calcium channel.

KW - Basophils

KW - Cell Membrane

KW - Histamine Release

KW - Humans

KW - Lanthanum

KW - Neuraminidase

KW - Nimodipine

KW - Sialic Acids

KW - Verapamil

M3 - Journal article

C2 - 2438678

VL - 60

SP - 214

EP - 216

JO - Pharmacology and Toxicology

JF - Pharmacology and Toxicology

SN - 0901-9928

IS - 3

ER -

ID: 43350489