Synthesis and biological evaluation of conformationally restricted and nucleobase-modified analogs of the anticancer compound 3'-C-ethynylcytidine (ECyd)
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A series of conformationally restricted and nucleobase-modified analogs of the anticancer compound 3'-C-ethynylcytidine (ECyd) and its uracil analog (EUrd) have been synthesized. While none of the conformationally restricted analogs displayed anticancer activity, 5-iodo-EUrd and 5-bromo-EUrd displayed potent anticancer activity with IC50 values of 35 nM and 0. 73 microM.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Nucleosides, nucleotides & nucleic acids |
| Vol/bind | 24 |
| Udgave nummer | 5-7 |
| Sider (fra-til) | 397-400 |
| Antal sider | 4 |
| ISSN | 1525-7770 |
| Status | Udgivet - 2005 |
| Eksternt udgivet | Ja |
ID: 59322958