Maurizio Sessa
Lektor
Farmaceutisk Informatik
Universitetsparken 2
2100 København Ø
Older adults are the main consumers of drugs but are rarely included in pivotal randomized clinical trials. Hence, post-marketing surveillance is a pivotal activity to better characterize the safety and effectiveness of medications in older patients.
I am currently coordinating a team integrating multidisciplinary expertise from Pharmacoepidemiology, Pharmacovigilance, and Data science to catalyze the identification of subgroups of older patients at higher risk of adverse drug reactions or not sufficiently benefitting from pharmacological treatments using post-marketing data sources (e.g., administrative and spontaneous reporting databases). The team has a strong translational perspective as its final goal is to promote the integration of discoveries into patient care.
The team has access to the biggest cohort of older individuals in Denmark covering the entire Danish population aged ≥ 65 for which they have socio-demographic information, hospital- and ambulatory access to Danish hospitals, pharmacological and non-pharmacological treatments, laboratory results (i.e., biochemical, genetic, and immunological), surgery, and procedures.
Primære forskningsområder
Pharmacovigilance and Pharmacoepidemiology
Aktuel forskning
Research projects currently under investigation include:
- Identification and risk minimization of potentially inappropriate prescriptions in older patients by using Danish administrative registers;
- Machine learning methods for automatized covariate selections to outperform the high-dimensional propensity score algorithm in Danish administrative registers;
- Development of new algorithms for assessing the duration of treatment episodes in Danish administrative data.
Mulige interessekonflikter
My postdoc was supported by a grant from the Novo Nordisk Foundation to the University of Copenhagen (NNF15SA0018404).
I received research grants or travel stipends from:
- Helsefonden (20-B-0059);
- Lundbeckfonden (R315-2019-312);
- NordForsk (105670).
Interesseområder
Pharmacovigilance
Pharmacoepidemiology
Clinical epidemiology
Udvalgte publikationer
- Udgivet
Predictors of quetiapine extended release formulation Add-On in older patients exposed to antidepressant drugs: A Danish Register-Based cohort study
Hashimi, H., Andersen, Morten & Sessa, Maurizio, 2020, I: International Journal of Geriatric Psychiatry. 35, 10, s. 1156-1162Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
- Udgivet
The risk of fractures, acute myocardial infarction, atrial fibrillation and ventricular arrhythmia in geriatric patients exposed to promethazine
Sessa, Maurizio, Mascolo, A., Dalhoff, Kim & Andersen, Morten, 2020, I: Expert Opinion on Drug Safety. 19, 3, s. 349-357Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
- Udgivet
Artificial Intelligence in Pharmacoepidemiology: A Systematic Review. Part 1—Overview of Knowledge Discovery Techniques in Artificial Intelligence
Sessa, Maurizio, Khan, A. R., Liang, D., Andersen, Morten & Kulahci, M., 2020, I: Frontiers in Pharmacology. 11, 18 s., 1028.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
- Udgivet
Metoprolol versus Carvedilol in Patients with Heart Failure, Chronic Obstructive Pulmonary Disease, Diabetes Mellitus, and Renal Failure
Sessa, Maurizio, Rasmussen, D. B., Jensen, M. T., Kragholm, K., Torp-pedersen, C. & Andersen, Morten, 1 jan. 2020, I: The American Journal of Cardiology. 125, 7, s. 1069-1076Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
- Udgivet
Utilizing drug-target-event relationships to unveil safety patterns in pharmacovigilance
Hauser, Alexander Sebastian, Kooistra, Albert J., Sverrisdóttir, E. & Sessa, Maurizio, 2020, I: Expert Opinion on Drug Safety. 19, s. 961-968Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
ID: 196196554
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Contribution of Italian clinical research for contrast media-induced nonrenal adverse drug reactions over the last three decades: A systematic review
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Predictors of new oral anticoagulant drug initiation as opposed to warfarin in elderly adults: A retrospective observational study in Southern Italy
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Pillars and Pitfalls of the New Pharmacovigilance Legislation: Consequences for the Identification of Adverse Drug Reactions Deriving From Abuse, Misuse, Overdose, Occupational Exposure, and Medication Errors
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