Immune-to-Brain Signaling Effects on the Neural Substrate for Reward: Behavioral Models of Aversion, Anhedonia, and Despair

Publikation: Bidrag til bog/antologi/rapportBidrag til bog/antologiForskningfagfællebedømt

  • Anna Mathia Klawonn
  • Michael Fritz

The role of immune-to-brain signaling in regulating mood and motivational states has received increasing interest, as clinical studies have uncovered a link between systemic inflammation and treatment-resistant major depressive disorder. With these findings, a need for relevant preclinical rodent models has arisen for investigating the role of systemic inflammation and immune-to-brain signaling on motivated behaviors. Here we describe some of the behavioral paradigms currently employed for examining inflammation-induced negative effect and malaise; more specifically we give examples of how the proinflammatory stimulus Escherichia coli lipopolysaccharide (LPS) can be combined with behavioral paradigms for anhedonia, aversion, and despair. We aim to provide the reader with guidance on how to prepare and conduct experiments exploring the effects of LPS induced systemic inflammation on affective behaviors.

OriginalsprogEngelsk
TitelNeuromethods
ForlagHumana Press
Publikationsdato2021
Sider145-167
Kapitel7
ISBN (Trykt)978-1-0716-1145-6
DOI
StatusUdgivet - 2021
NavnNeuromethods
Vol/bind165
ISSN0893-2336

Bibliografisk note

Publisher Copyright:
© 2021, Springer Science+Business Media, LLC, part of Springer Nature.

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