Assessing the nature of premature responses in the rodent continuous performance test variable intertrial interval schedule using atomoxetine and amphetamine
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Assessing the nature of premature responses in the rodent continuous performance test variable intertrial interval schedule using atomoxetine and amphetamine. / Prichardt, S.; Caballero-Puntiverio, M.; Klem, L.; Arvastson, L.; Lerdrup, L.; Andreasen, J. T.
I: Journal of Neuroscience Methods, Bind 384, 109749, 2023.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Assessing the nature of premature responses in the rodent continuous performance test variable intertrial interval schedule using atomoxetine and amphetamine
AU - Prichardt, S.
AU - Caballero-Puntiverio, M.
AU - Klem, L.
AU - Arvastson, L.
AU - Lerdrup, L.
AU - Andreasen, J. T.
PY - 2023
Y1 - 2023
N2 - Background: Rodent operant tests that include premature responses (PR) as a measure of impulsivity commonly use variable intertrial interval (vITI) schedules. The rodent continuous performance test (rCPT) is suitable for a vITI schedule.New Method: We optimised the analysis for a rCPT vITI schedule with intertrial intervals (ITIs) of 3, 6, and 12 s. Examining the nature of first (FiT) and following touches (FoT) to the blank screen led to a separate quantifi-cation of these two behaviours into the first touches level (%FiT) and the following-to-first touches ratio (FoT/ FiT).Results: FiTs occurred more frequently in the 12 s ITIs than at shorter ITIs. Within 12 s ITIs, %FiT was only moderately higher during the last half than the first half, suggesting that long ITIs have a minimal effect on impulsivity, but allow a longer time for its detection. %FiT and the FoT/FiT ratio were uncorrelated. %FiT was negatively correlated with response criterion (C) and uncorrelated with discriminability. Conversely, FoT/FiT ratio was negatively correlated with discriminability, without correlation to C. Atomoxetine decreased %FiT but did not affect FoT/FiT ratio. Amphetamine increased %FiT and decreased the FoT/FiT ratio.Comparison with Existing Method(s): The results suggest that %FiT is analogous to %PR in related tasks and is a more suitable measure of waiting impulsivity in the rCPT. FoT/FiT ratio is unrelated to %FiT. Conclusions: Long ITIs increase the detectability of, but has minimal effect on, waiting impulsivity. %FiT is analogous to %PR in related tasks, while the FoT/FiT ratio is a separate behaviour requiring further characterization.
AB - Background: Rodent operant tests that include premature responses (PR) as a measure of impulsivity commonly use variable intertrial interval (vITI) schedules. The rodent continuous performance test (rCPT) is suitable for a vITI schedule.New Method: We optimised the analysis for a rCPT vITI schedule with intertrial intervals (ITIs) of 3, 6, and 12 s. Examining the nature of first (FiT) and following touches (FoT) to the blank screen led to a separate quantifi-cation of these two behaviours into the first touches level (%FiT) and the following-to-first touches ratio (FoT/ FiT).Results: FiTs occurred more frequently in the 12 s ITIs than at shorter ITIs. Within 12 s ITIs, %FiT was only moderately higher during the last half than the first half, suggesting that long ITIs have a minimal effect on impulsivity, but allow a longer time for its detection. %FiT and the FoT/FiT ratio were uncorrelated. %FiT was negatively correlated with response criterion (C) and uncorrelated with discriminability. Conversely, FoT/FiT ratio was negatively correlated with discriminability, without correlation to C. Atomoxetine decreased %FiT but did not affect FoT/FiT ratio. Amphetamine increased %FiT and decreased the FoT/FiT ratio.Comparison with Existing Method(s): The results suggest that %FiT is analogous to %PR in related tasks and is a more suitable measure of waiting impulsivity in the rCPT. FoT/FiT ratio is unrelated to %FiT. Conclusions: Long ITIs increase the detectability of, but has minimal effect on, waiting impulsivity. %FiT is analogous to %PR in related tasks, while the FoT/FiT ratio is a separate behaviour requiring further characterization.
KW - Variable inter-trial interval
KW - Rodent continuous performance test
KW - Impulsivity
KW - Premature response
KW - Atomoxetine
KW - Amphetamine
KW - REACTION-TIME-TASK
KW - ATTENTIONAL PERFORMANCE
KW - DISTINCT FORMS
KW - TEST RCPT
KW - IMPULSIVITY
KW - RATS
KW - LESIONS
KW - ADHD
KW - METHYLPHENIDATE
KW - STIMULANTS
U2 - 10.1016/j.jneumeth.2022.109749
DO - 10.1016/j.jneumeth.2022.109749
M3 - Journal article
C2 - 36414103
VL - 384
JO - Journal of Neuroscience Methods
JF - Journal of Neuroscience Methods
SN - 0165-0270
M1 - 109749
ER -
ID: 333702659