Convenient access to β-substituted cysteines and β- and γ-mercapto prolines
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Herein we describe a convenient method for the synthesis of the ,8-substituted Cys analogs 1a, b and trans-,8-mercapto proline 1c, from their corresponding a ,,8-unsaturated-a-amino esters using p-methoxybenzyl mercaptan as the sulfur source. The intermediate ,8-thioethers are stable toward chromatographic purification, and after global deprotection the ,8-mercapto amino acids 1a-c are obtained in good to high yields (64%-99%).
Originalsprog | Engelsk |
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Tidsskrift | Canadian Journal of Chemistry |
Vol/bind | 101 |
Udgave nummer | 5 |
Sider (fra-til) | 326-333 |
ISSN | 0008-4042 |
DOI | |
Status | Udgivet - 2023 |
ID: 341260058