Diastereodivergent Access to Syn and Anti 3,4-Substituted β-Fluoropyrrolidines: Enhancing or Reversing Substrate Preference
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A practical diastereodivergent access to β-fluoropyrrolidines with two adjacent stereocenters has been demonstrated, by either enhancing or completely reversing the substrate control, in the diastereoselective fluorination of a series of diverse pyrrolidinyl carbaldehydes using organocatalysis. Furthermore, enamine catalysis has been successfully utilized for kinetic resolution, obtaining a fluorinated β-prolinol analogue with two adjacent tetrasubstituted chiral centers in 95% ee from a racemic substrate.
Originalsprog | Engelsk |
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Tidsskrift | Organic Letters |
Vol/bind | 18 |
Udgave nummer | 5 |
Sider (fra-til) | 1170-1173 |
Antal sider | 4 |
ISSN | 1523-7060 |
DOI | |
Status | Udgivet - 2016 |
ID: 156078052