Erythrina Alkaloid Analogues as nAChR Antagonists-A Flexible Platform for Leads in Drug Discovery
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Erythrina alkaloids and their central nervous system effects have been studied for over a century, mainly due to their potent antagonistic actions at β2-containing nicotinic acetylcholine receptors (nAChRs). In the present work, we report a synthetic approach giving access to a diverse set of Erythrina natural product analogues and present the enantioselective total synthesis of (+)-Cocculine and (+)-Cocculidine, both found to be potent antagonists of the β2-containing nAChRs.
Originalsprog | Engelsk |
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Tidsskrift | The Journal of Organic Chemistry |
Vol/bind | 86 |
Udgave nummer | 12 |
Sider (fra-til) | 8248-8262 |
ISSN | 0022-3263 |
DOI | |
Status | Udgivet - 2021 |
ID: 270553746