G proteinsãre the major signal proteins of ∼800 receptors for medicines, hormones, neurotransmitters, tãstãntsãnd odorants. GproteinDb offers integrated genomic, str uct ural,ãnd pharmacological dataãnd tools forãnalysis, visualizationãnd experiment design. Here, we present the first major update of GproteinDb greatly expanding its coupling dataãnd str uct ural templates,ãdding AlphaFold2 str uct ure models of GPCR-G protein comple x esãndãdvãncing the interactiv eãnaly sis tools f or their interfãces underlying coupling selectivity. We present insights on couplingãgreementãcross datasetsãnd parameters, including constitutiveãctivity,ãgonist-inducedãctivityãnd kinetics. GproteinDb isãccessibleãt https://gproteindb.org .