Increased serum ß2-microglobulin is associated with clinical and immunological markers of disease activity in systemic lupus erythematosus patients

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Standard

Increased serum ß2-microglobulin is associated with clinical and immunological markers of disease activity in systemic lupus erythematosus patients. / Hermansen, M-L F; Hummelshøj, L; Lundsgaard, Dorte; Hornum, L; Keller, P; Fleckner, J; Fox, B; Poulsen, Lars K.; Jacobsen, S.

I: Lupus Now, Bind 21, Nr. 10, 2012, s. 1098-104.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Hermansen, M-LF, Hummelshøj, L, Lundsgaard, D, Hornum, L, Keller, P, Fleckner, J, Fox, B, Poulsen, LK & Jacobsen, S 2012, 'Increased serum ß2-microglobulin is associated with clinical and immunological markers of disease activity in systemic lupus erythematosus patients', Lupus Now, bind 21, nr. 10, s. 1098-104. https://doi.org/10.1177/0961203312447668

APA

Hermansen, M-L. F., Hummelshøj, L., Lundsgaard, D., Hornum, L., Keller, P., Fleckner, J., Fox, B., Poulsen, L. K., & Jacobsen, S. (2012). Increased serum ß2-microglobulin is associated with clinical and immunological markers of disease activity in systemic lupus erythematosus patients. Lupus Now, 21(10), 1098-104. https://doi.org/10.1177/0961203312447668

Vancouver

Hermansen M-LF, Hummelshøj L, Lundsgaard D, Hornum L, Keller P, Fleckner J o.a. Increased serum ß2-microglobulin is associated with clinical and immunological markers of disease activity in systemic lupus erythematosus patients. Lupus Now. 2012;21(10):1098-104. https://doi.org/10.1177/0961203312447668

Author

Hermansen, M-L F ; Hummelshøj, L ; Lundsgaard, Dorte ; Hornum, L ; Keller, P ; Fleckner, J ; Fox, B ; Poulsen, Lars K. ; Jacobsen, S. / Increased serum ß2-microglobulin is associated with clinical and immunological markers of disease activity in systemic lupus erythematosus patients. I: Lupus Now. 2012 ; Bind 21, Nr. 10. s. 1098-104.

Bibtex

@article{2fd3af5dc24c4e5b8a495d637d4c0039,
title = "Increased serum {\ss}2-microglobulin is associated with clinical and immunological markers of disease activity in systemic lupus erythematosus patients",
abstract = "The objective of this study was to explore the relationship between serum levels of {\ss}2-microglobulin ({\ss}2MG), which some studies suggest reflect disease activity in systemic lupus erythematosus (SLE), and various clinical and immunological markers of disease activity in SLE. Twenty-six SLE patients and 10 healthy controls were included. Disease activity was assessed by: SLEDAI, 24¿hr-proteinuria, circulating levels of complement C3, anti-double-stranded DNA (anti-dsDNA), {\ss}2MG and various pro-inflammatory and anti-inflammatory cytokines (IL-6, IL-8, IL-10, IL-18) measured with a multiplex assay, IFN-a assessed with a reporter gene assay, and a combined expression score of 12 IFN-a inducible genes in peripheral blood mononuclear cells. Median serum levels of {\ss}2MG were significantly higher in SLE patients vs controls (2.8¿mg/L, range: 1.1-21.6 and 1.2¿mg/L, range: 0.9-1.7, respectively, p¿",
author = "Hermansen, {M-L F} and L Hummelsh{\o}j and Dorte Lundsgaard and L Hornum and P Keller and J Fleckner and B Fox and Poulsen, {Lars K.} and S Jacobsen",
year = "2012",
doi = "10.1177/0961203312447668",
language = "English",
volume = "21",
pages = "1098--104",
journal = "Lupus Now",
issn = "1547-1780",
number = "10",

}

RIS

TY - JOUR

T1 - Increased serum ß2-microglobulin is associated with clinical and immunological markers of disease activity in systemic lupus erythematosus patients

AU - Hermansen, M-L F

AU - Hummelshøj, L

AU - Lundsgaard, Dorte

AU - Hornum, L

AU - Keller, P

AU - Fleckner, J

AU - Fox, B

AU - Poulsen, Lars K.

AU - Jacobsen, S

PY - 2012

Y1 - 2012

N2 - The objective of this study was to explore the relationship between serum levels of ß2-microglobulin (ß2MG), which some studies suggest reflect disease activity in systemic lupus erythematosus (SLE), and various clinical and immunological markers of disease activity in SLE. Twenty-six SLE patients and 10 healthy controls were included. Disease activity was assessed by: SLEDAI, 24¿hr-proteinuria, circulating levels of complement C3, anti-double-stranded DNA (anti-dsDNA), ß2MG and various pro-inflammatory and anti-inflammatory cytokines (IL-6, IL-8, IL-10, IL-18) measured with a multiplex assay, IFN-a assessed with a reporter gene assay, and a combined expression score of 12 IFN-a inducible genes in peripheral blood mononuclear cells. Median serum levels of ß2MG were significantly higher in SLE patients vs controls (2.8¿mg/L, range: 1.1-21.6 and 1.2¿mg/L, range: 0.9-1.7, respectively, p¿

AB - The objective of this study was to explore the relationship between serum levels of ß2-microglobulin (ß2MG), which some studies suggest reflect disease activity in systemic lupus erythematosus (SLE), and various clinical and immunological markers of disease activity in SLE. Twenty-six SLE patients and 10 healthy controls were included. Disease activity was assessed by: SLEDAI, 24¿hr-proteinuria, circulating levels of complement C3, anti-double-stranded DNA (anti-dsDNA), ß2MG and various pro-inflammatory and anti-inflammatory cytokines (IL-6, IL-8, IL-10, IL-18) measured with a multiplex assay, IFN-a assessed with a reporter gene assay, and a combined expression score of 12 IFN-a inducible genes in peripheral blood mononuclear cells. Median serum levels of ß2MG were significantly higher in SLE patients vs controls (2.8¿mg/L, range: 1.1-21.6 and 1.2¿mg/L, range: 0.9-1.7, respectively, p¿

U2 - 10.1177/0961203312447668

DO - 10.1177/0961203312447668

M3 - Journal article

C2 - 22577117

VL - 21

SP - 1098

EP - 1104

JO - Lupus Now

JF - Lupus Now

SN - 1547-1780

IS - 10

ER -

ID: 43534765