Structure activity relationship of selective GABA uptake inhibitors

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningfagfællebedømt

A series of β-amino acids with lipophilic diaromatic side chain was synthesized and characterized pharmacologically on mouse γ-amino butyric acid (GABA) transporter subtypes mGAT1-4 in order to investigate structure activity relationships (SAR) for mGAT2 (corresponding to hBGT-1). Variation in the lipophilic diaromatic side chain was probed to understand the role of the side chain for activity. This yielded several selective compounds of which the best (1R,2S)-5a was more than 10 fold selective towards other subtypes, although potency was moderate. A docking study was performed to investigate possible binding modes of the compounds in mGAT2 suggesting a binding mode similar to that proposed for Tiagabine in hGAT1. Specific interactions between the transporter and the amino acid part of the ligands may account for a reverted preference towards mGAT2 over mGAT1.

OriginalsprogEngelsk
TidsskriftBioorganic & Medicinal Chemistry
Vol/bind23
Udgave nummer10
Sider (fra-til)2480-2488
Antal sider9
ISSN0968-0896
DOI
StatusUdgivet - 15 maj 2015

ID: 136801762