Invited Lecture: From Host Defence Peptides to New Antibiotics
Publikation: Konferencebidrag › Konferenceabstrakt til konference › Forskning
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Invited Lecture: From Host Defence Peptides to New Antibiotics. / Hansen, Paul Robert.
2014. Abstract fra Antibiotic alternatives for the new millennium, London, Storbritannien.Publikation: Konferencebidrag › Konferenceabstrakt til konference › Forskning
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TY - ABST
T1 - Invited Lecture: From Host Defence Peptides to New Antibiotics
AU - Hansen, Paul Robert
PY - 2014
Y1 - 2014
N2 - Antimicrobial peptides hold promise as the next generation of antimicrobial agents. However, the potential is weakened by their susceptibility to proteolytic degradation, poor bioavailabillity , toxicity and high cost. Our research interest is in determining the structure/activity relationships of these antimicrobial peptides, which enables us to better understand their mechanism of action and facilitates the development of lead antimicrobial agents. As an example, in this talk I will focus on our work on anoplin and analogues, a decapeptide isolated from the Japanese wasp Anoplius samariensis. I will describe the elucidation of their structure/activity relationships, and our efforts towards developing them into antibiotics.
AB - Antimicrobial peptides hold promise as the next generation of antimicrobial agents. However, the potential is weakened by their susceptibility to proteolytic degradation, poor bioavailabillity , toxicity and high cost. Our research interest is in determining the structure/activity relationships of these antimicrobial peptides, which enables us to better understand their mechanism of action and facilitates the development of lead antimicrobial agents. As an example, in this talk I will focus on our work on anoplin and analogues, a decapeptide isolated from the Japanese wasp Anoplius samariensis. I will describe the elucidation of their structure/activity relationships, and our efforts towards developing them into antibiotics.
M3 - Conference abstract for conference
T2 - Antibiotic alternatives for the new millennium
Y2 - 5 November 2014 through 7 November 2014
ER -
ID: 127141479