Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship

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Standard

Nine new human Rhodopsin family G-protein coupled receptors : identification, sequence characterisation and evolutionary relationship. / Gloriam, David E.; Schiöth, Helgi B; Fredriksson, Robert.

I: BBA General Subjects, Bind 1722, Nr. 3, 15.04.2005, s. 235-46.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Gloriam, DE, Schiöth, HB & Fredriksson, R 2005, 'Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship', BBA General Subjects, bind 1722, nr. 3, s. 235-46. https://doi.org/10.1016/j.bbagen.2004.12.001

APA

Gloriam, D. E., Schiöth, H. B., & Fredriksson, R. (2005). Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship. BBA General Subjects, 1722(3), 235-46. https://doi.org/10.1016/j.bbagen.2004.12.001

Vancouver

Gloriam DE, Schiöth HB, Fredriksson R. Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship. BBA General Subjects. 2005 apr. 15;1722(3):235-46. https://doi.org/10.1016/j.bbagen.2004.12.001

Author

Gloriam, David E. ; Schiöth, Helgi B ; Fredriksson, Robert. / Nine new human Rhodopsin family G-protein coupled receptors : identification, sequence characterisation and evolutionary relationship. I: BBA General Subjects. 2005 ; Bind 1722, Nr. 3. s. 235-46.

Bibtex

@article{5663a741a3be42ffbefc1dea00a95094,
title = "Nine new human Rhodopsin family G-protein coupled receptors: identification, sequence characterisation and evolutionary relationship",
abstract = "We report nine new members of the Rhodopsin family of human G protein-coupled receptors (GPCRs) found by searches in the genome databases. BLAST searches and phylogenetic analyses showed that only four of the receptors are closely related to previously characterised GPCRs, GPR150 and GPR154 to oxytocin/vasopressin receptors, GPR152 to CRTH2/FPRs and GPR165 to GPR72/NPYR. Four of the receptors, GPR139, GPR146, GPR153 and GPR162, have one other orphan GPCRs as close relative while GPR148 lacks close relatives. We have identified in total 37 orthologues for the new receptors, primarily from rat, mouse, chicken, fugu and zebrafish. GPR162 and GPR139 are remarkably well conserved while GPR148 seems to be evolving rapidly. Analyses using expressed sequence tags (ESTs) indicate that all the new receptors except GPR153 have the CNS as a major site of expression.",
keywords = "Expressed Sequence Tags, Humans, Phylogeny, Receptors, G-Protein-Coupled, Rhodopsin",
author = "Gloriam, {David E.} and Schi{\"o}th, {Helgi B} and Robert Fredriksson",
year = "2005",
month = apr,
day = "15",
doi = "10.1016/j.bbagen.2004.12.001",
language = "English",
volume = "1722",
pages = "235--46",
journal = "B B A - General Subjects",
issn = "0304-4165",
publisher = "Elsevier",
number = "3",

}

RIS

TY - JOUR

T1 - Nine new human Rhodopsin family G-protein coupled receptors

T2 - identification, sequence characterisation and evolutionary relationship

AU - Gloriam, David E.

AU - Schiöth, Helgi B

AU - Fredriksson, Robert

PY - 2005/4/15

Y1 - 2005/4/15

N2 - We report nine new members of the Rhodopsin family of human G protein-coupled receptors (GPCRs) found by searches in the genome databases. BLAST searches and phylogenetic analyses showed that only four of the receptors are closely related to previously characterised GPCRs, GPR150 and GPR154 to oxytocin/vasopressin receptors, GPR152 to CRTH2/FPRs and GPR165 to GPR72/NPYR. Four of the receptors, GPR139, GPR146, GPR153 and GPR162, have one other orphan GPCRs as close relative while GPR148 lacks close relatives. We have identified in total 37 orthologues for the new receptors, primarily from rat, mouse, chicken, fugu and zebrafish. GPR162 and GPR139 are remarkably well conserved while GPR148 seems to be evolving rapidly. Analyses using expressed sequence tags (ESTs) indicate that all the new receptors except GPR153 have the CNS as a major site of expression.

AB - We report nine new members of the Rhodopsin family of human G protein-coupled receptors (GPCRs) found by searches in the genome databases. BLAST searches and phylogenetic analyses showed that only four of the receptors are closely related to previously characterised GPCRs, GPR150 and GPR154 to oxytocin/vasopressin receptors, GPR152 to CRTH2/FPRs and GPR165 to GPR72/NPYR. Four of the receptors, GPR139, GPR146, GPR153 and GPR162, have one other orphan GPCRs as close relative while GPR148 lacks close relatives. We have identified in total 37 orthologues for the new receptors, primarily from rat, mouse, chicken, fugu and zebrafish. GPR162 and GPR139 are remarkably well conserved while GPR148 seems to be evolving rapidly. Analyses using expressed sequence tags (ESTs) indicate that all the new receptors except GPR153 have the CNS as a major site of expression.

KW - Expressed Sequence Tags

KW - Humans

KW - Phylogeny

KW - Receptors, G-Protein-Coupled

KW - Rhodopsin

U2 - 10.1016/j.bbagen.2004.12.001

DO - 10.1016/j.bbagen.2004.12.001

M3 - Journal article

C2 - 15777626

VL - 1722

SP - 235

EP - 246

JO - B B A - General Subjects

JF - B B A - General Subjects

SN - 0304-4165

IS - 3

ER -

ID: 45811696