An inverse association between plasma benzoxazinoid metabolites and PSA after rye intake in men with prostate cancer revealed with a new method

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Standard

An inverse association between plasma benzoxazinoid metabolites and PSA after rye intake in men with prostate cancer revealed with a new method. / Nordin, Elise; Steffensen, Stine K.; Laursen, Bente B.; Andersson, Sven-Oluf; Johansson, Jan-Erik; Åman, Per; Hallmans, Göran; Borre, Michael; Stærk, Dan; Hanhineva, Kati; Fomsgaard, Inge S.; Landberg, Rikard.

I: Scientific Reports, Bind 12, 5260, 2022.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Nordin, E, Steffensen, SK, Laursen, BB, Andersson, S-O, Johansson, J-E, Åman, P, Hallmans, G, Borre, M, Stærk, D, Hanhineva, K, Fomsgaard, IS & Landberg, R 2022, 'An inverse association between plasma benzoxazinoid metabolites and PSA after rye intake in men with prostate cancer revealed with a new method', Scientific Reports, bind 12, 5260. https://doi.org/10.1038/s41598-022-08856-z

APA

Nordin, E., Steffensen, S. K., Laursen, B. B., Andersson, S-O., Johansson, J-E., Åman, P., Hallmans, G., Borre, M., Stærk, D., Hanhineva, K., Fomsgaard, I. S., & Landberg, R. (2022). An inverse association between plasma benzoxazinoid metabolites and PSA after rye intake in men with prostate cancer revealed with a new method. Scientific Reports, 12, [5260]. https://doi.org/10.1038/s41598-022-08856-z

Vancouver

Nordin E, Steffensen SK, Laursen BB, Andersson S-O, Johansson J-E, Åman P o.a. An inverse association between plasma benzoxazinoid metabolites and PSA after rye intake in men with prostate cancer revealed with a new method. Scientific Reports. 2022;12. 5260. https://doi.org/10.1038/s41598-022-08856-z

Author

Nordin, Elise ; Steffensen, Stine K. ; Laursen, Bente B. ; Andersson, Sven-Oluf ; Johansson, Jan-Erik ; Åman, Per ; Hallmans, Göran ; Borre, Michael ; Stærk, Dan ; Hanhineva, Kati ; Fomsgaard, Inge S. ; Landberg, Rikard. / An inverse association between plasma benzoxazinoid metabolites and PSA after rye intake in men with prostate cancer revealed with a new method. I: Scientific Reports. 2022 ; Bind 12.

Bibtex

@article{63da586858ed4cb1936f4b735e7f92c4,
title = "An inverse association between plasma benzoxazinoid metabolites and PSA after rye intake in men with prostate cancer revealed with a new method",
abstract = "Prostate cancer (PC) is a common cancer among men, and preventive strategies are warranted. Benzoxazinoids (BXs) in rye have shown potential against PC in vitro but human studies are lacking. The aim was to establish a quantitative method for analysis of BXs and investigate their plasma levels after a whole grain/bran rye vs refined wheat intervention, as well as exploring their association with PSA, in men with PC. A quantitative method for analysis of 22 BXs, including novel metabolites identified by mass spectrometry and NMR, was established, and applied to plasma samples from a randomized crossover study where patients with indolent PC (n = 17) consumed 485 g whole grain rye/rye bran or fiber supplemented refined wheat daily for 6 wk. Most BXs were significantly higher in plasma after rye (0.3–19.4 nmol/L in plasma) vs. refined wheat (0.05–2.9 nmol/L) intake. HBOA-glc, 2-HHPAA, HBOA-glcA, 2-HPAA-glcA were inversely correlated to PSA in plasma (p < 0.04). To conclude, BXs in plasma, including metabolites not previously analyzed, were quantified. BX metabolites were significantly higher after rye vs refined wheat consumption. Four BX-related metabolites were inversely associated with PSA, which merits further investigation.",
author = "Elise Nordin and Steffensen, {Stine K.} and Laursen, {Bente B.} and Sven-Oluf Andersson and Jan-Erik Johansson and Per {\AA}man and G{\"o}ran Hallmans and Michael Borre and Dan St{\ae}rk and Kati Hanhineva and Fomsgaard, {Inge S.} and Rikard Landberg",
year = "2022",
doi = "10.1038/s41598-022-08856-z",
language = "English",
volume = "12",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - An inverse association between plasma benzoxazinoid metabolites and PSA after rye intake in men with prostate cancer revealed with a new method

AU - Nordin, Elise

AU - Steffensen, Stine K.

AU - Laursen, Bente B.

AU - Andersson, Sven-Oluf

AU - Johansson, Jan-Erik

AU - Åman, Per

AU - Hallmans, Göran

AU - Borre, Michael

AU - Stærk, Dan

AU - Hanhineva, Kati

AU - Fomsgaard, Inge S.

AU - Landberg, Rikard

PY - 2022

Y1 - 2022

N2 - Prostate cancer (PC) is a common cancer among men, and preventive strategies are warranted. Benzoxazinoids (BXs) in rye have shown potential against PC in vitro but human studies are lacking. The aim was to establish a quantitative method for analysis of BXs and investigate their plasma levels after a whole grain/bran rye vs refined wheat intervention, as well as exploring their association with PSA, in men with PC. A quantitative method for analysis of 22 BXs, including novel metabolites identified by mass spectrometry and NMR, was established, and applied to plasma samples from a randomized crossover study where patients with indolent PC (n = 17) consumed 485 g whole grain rye/rye bran or fiber supplemented refined wheat daily for 6 wk. Most BXs were significantly higher in plasma after rye (0.3–19.4 nmol/L in plasma) vs. refined wheat (0.05–2.9 nmol/L) intake. HBOA-glc, 2-HHPAA, HBOA-glcA, 2-HPAA-glcA were inversely correlated to PSA in plasma (p < 0.04). To conclude, BXs in plasma, including metabolites not previously analyzed, were quantified. BX metabolites were significantly higher after rye vs refined wheat consumption. Four BX-related metabolites were inversely associated with PSA, which merits further investigation.

AB - Prostate cancer (PC) is a common cancer among men, and preventive strategies are warranted. Benzoxazinoids (BXs) in rye have shown potential against PC in vitro but human studies are lacking. The aim was to establish a quantitative method for analysis of BXs and investigate their plasma levels after a whole grain/bran rye vs refined wheat intervention, as well as exploring their association with PSA, in men with PC. A quantitative method for analysis of 22 BXs, including novel metabolites identified by mass spectrometry and NMR, was established, and applied to plasma samples from a randomized crossover study where patients with indolent PC (n = 17) consumed 485 g whole grain rye/rye bran or fiber supplemented refined wheat daily for 6 wk. Most BXs were significantly higher in plasma after rye (0.3–19.4 nmol/L in plasma) vs. refined wheat (0.05–2.9 nmol/L) intake. HBOA-glc, 2-HHPAA, HBOA-glcA, 2-HPAA-glcA were inversely correlated to PSA in plasma (p < 0.04). To conclude, BXs in plasma, including metabolites not previously analyzed, were quantified. BX metabolites were significantly higher after rye vs refined wheat consumption. Four BX-related metabolites were inversely associated with PSA, which merits further investigation.

U2 - 10.1038/s41598-022-08856-z

DO - 10.1038/s41598-022-08856-z

M3 - Journal article

C2 - 35347164

VL - 12

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 5260

ER -

ID: 300290651