Assessing the nature of premature responses in the rodent continuous performance test variable intertrial interval schedule using atomoxetine and amphetamine

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Assessing the nature of premature responses in the rodent continuous performance test variable intertrial interval schedule using atomoxetine and amphetamine. / Prichardt, S.; Caballero-Puntiverio, M.; Klem, L.; Arvastson, L.; Lerdrup, L.; Andreasen, J. T.

I: Journal of Neuroscience Methods, Bind 384, 109749, 2023.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Prichardt, S, Caballero-Puntiverio, M, Klem, L, Arvastson, L, Lerdrup, L & Andreasen, JT 2023, 'Assessing the nature of premature responses in the rodent continuous performance test variable intertrial interval schedule using atomoxetine and amphetamine', Journal of Neuroscience Methods, bind 384, 109749. https://doi.org/10.1016/j.jneumeth.2022.109749

APA

Prichardt, S., Caballero-Puntiverio, M., Klem, L., Arvastson, L., Lerdrup, L., & Andreasen, J. T. (2023). Assessing the nature of premature responses in the rodent continuous performance test variable intertrial interval schedule using atomoxetine and amphetamine. Journal of Neuroscience Methods, 384, [109749]. https://doi.org/10.1016/j.jneumeth.2022.109749

Vancouver

Prichardt S, Caballero-Puntiverio M, Klem L, Arvastson L, Lerdrup L, Andreasen JT. Assessing the nature of premature responses in the rodent continuous performance test variable intertrial interval schedule using atomoxetine and amphetamine. Journal of Neuroscience Methods. 2023;384. 109749. https://doi.org/10.1016/j.jneumeth.2022.109749

Author

Prichardt, S. ; Caballero-Puntiverio, M. ; Klem, L. ; Arvastson, L. ; Lerdrup, L. ; Andreasen, J. T. / Assessing the nature of premature responses in the rodent continuous performance test variable intertrial interval schedule using atomoxetine and amphetamine. I: Journal of Neuroscience Methods. 2023 ; Bind 384.

Bibtex

@article{3b560bbda633497a9ee01d1b7c110648,
title = "Assessing the nature of premature responses in the rodent continuous performance test variable intertrial interval schedule using atomoxetine and amphetamine",
abstract = "Background: Rodent operant tests that include premature responses (PR) as a measure of impulsivity commonly use variable intertrial interval (vITI) schedules. The rodent continuous performance test (rCPT) is suitable for a vITI schedule.New Method: We optimised the analysis for a rCPT vITI schedule with intertrial intervals (ITIs) of 3, 6, and 12 s. Examining the nature of first (FiT) and following touches (FoT) to the blank screen led to a separate quantifi-cation of these two behaviours into the first touches level (%FiT) and the following-to-first touches ratio (FoT/ FiT).Results: FiTs occurred more frequently in the 12 s ITIs than at shorter ITIs. Within 12 s ITIs, %FiT was only moderately higher during the last half than the first half, suggesting that long ITIs have a minimal effect on impulsivity, but allow a longer time for its detection. %FiT and the FoT/FiT ratio were uncorrelated. %FiT was negatively correlated with response criterion (C) and uncorrelated with discriminability. Conversely, FoT/FiT ratio was negatively correlated with discriminability, without correlation to C. Atomoxetine decreased %FiT but did not affect FoT/FiT ratio. Amphetamine increased %FiT and decreased the FoT/FiT ratio.Comparison with Existing Method(s): The results suggest that %FiT is analogous to %PR in related tasks and is a more suitable measure of waiting impulsivity in the rCPT. FoT/FiT ratio is unrelated to %FiT. Conclusions: Long ITIs increase the detectability of, but has minimal effect on, waiting impulsivity. %FiT is analogous to %PR in related tasks, while the FoT/FiT ratio is a separate behaviour requiring further characterization.",
keywords = "Variable inter-trial interval, Rodent continuous performance test, Impulsivity, Premature response, Atomoxetine, Amphetamine, REACTION-TIME-TASK, ATTENTIONAL PERFORMANCE, DISTINCT FORMS, TEST RCPT, IMPULSIVITY, RATS, LESIONS, ADHD, METHYLPHENIDATE, STIMULANTS",
author = "S. Prichardt and M. Caballero-Puntiverio and L. Klem and L. Arvastson and L. Lerdrup and Andreasen, {J. T.}",
year = "2023",
doi = "10.1016/j.jneumeth.2022.109749",
language = "English",
volume = "384",
journal = "Journal of Neuroscience Methods",
issn = "0165-0270",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Assessing the nature of premature responses in the rodent continuous performance test variable intertrial interval schedule using atomoxetine and amphetamine

AU - Prichardt, S.

AU - Caballero-Puntiverio, M.

AU - Klem, L.

AU - Arvastson, L.

AU - Lerdrup, L.

AU - Andreasen, J. T.

PY - 2023

Y1 - 2023

N2 - Background: Rodent operant tests that include premature responses (PR) as a measure of impulsivity commonly use variable intertrial interval (vITI) schedules. The rodent continuous performance test (rCPT) is suitable for a vITI schedule.New Method: We optimised the analysis for a rCPT vITI schedule with intertrial intervals (ITIs) of 3, 6, and 12 s. Examining the nature of first (FiT) and following touches (FoT) to the blank screen led to a separate quantifi-cation of these two behaviours into the first touches level (%FiT) and the following-to-first touches ratio (FoT/ FiT).Results: FiTs occurred more frequently in the 12 s ITIs than at shorter ITIs. Within 12 s ITIs, %FiT was only moderately higher during the last half than the first half, suggesting that long ITIs have a minimal effect on impulsivity, but allow a longer time for its detection. %FiT and the FoT/FiT ratio were uncorrelated. %FiT was negatively correlated with response criterion (C) and uncorrelated with discriminability. Conversely, FoT/FiT ratio was negatively correlated with discriminability, without correlation to C. Atomoxetine decreased %FiT but did not affect FoT/FiT ratio. Amphetamine increased %FiT and decreased the FoT/FiT ratio.Comparison with Existing Method(s): The results suggest that %FiT is analogous to %PR in related tasks and is a more suitable measure of waiting impulsivity in the rCPT. FoT/FiT ratio is unrelated to %FiT. Conclusions: Long ITIs increase the detectability of, but has minimal effect on, waiting impulsivity. %FiT is analogous to %PR in related tasks, while the FoT/FiT ratio is a separate behaviour requiring further characterization.

AB - Background: Rodent operant tests that include premature responses (PR) as a measure of impulsivity commonly use variable intertrial interval (vITI) schedules. The rodent continuous performance test (rCPT) is suitable for a vITI schedule.New Method: We optimised the analysis for a rCPT vITI schedule with intertrial intervals (ITIs) of 3, 6, and 12 s. Examining the nature of first (FiT) and following touches (FoT) to the blank screen led to a separate quantifi-cation of these two behaviours into the first touches level (%FiT) and the following-to-first touches ratio (FoT/ FiT).Results: FiTs occurred more frequently in the 12 s ITIs than at shorter ITIs. Within 12 s ITIs, %FiT was only moderately higher during the last half than the first half, suggesting that long ITIs have a minimal effect on impulsivity, but allow a longer time for its detection. %FiT and the FoT/FiT ratio were uncorrelated. %FiT was negatively correlated with response criterion (C) and uncorrelated with discriminability. Conversely, FoT/FiT ratio was negatively correlated with discriminability, without correlation to C. Atomoxetine decreased %FiT but did not affect FoT/FiT ratio. Amphetamine increased %FiT and decreased the FoT/FiT ratio.Comparison with Existing Method(s): The results suggest that %FiT is analogous to %PR in related tasks and is a more suitable measure of waiting impulsivity in the rCPT. FoT/FiT ratio is unrelated to %FiT. Conclusions: Long ITIs increase the detectability of, but has minimal effect on, waiting impulsivity. %FiT is analogous to %PR in related tasks, while the FoT/FiT ratio is a separate behaviour requiring further characterization.

KW - Variable inter-trial interval

KW - Rodent continuous performance test

KW - Impulsivity

KW - Premature response

KW - Atomoxetine

KW - Amphetamine

KW - REACTION-TIME-TASK

KW - ATTENTIONAL PERFORMANCE

KW - DISTINCT FORMS

KW - TEST RCPT

KW - IMPULSIVITY

KW - RATS

KW - LESIONS

KW - ADHD

KW - METHYLPHENIDATE

KW - STIMULANTS

U2 - 10.1016/j.jneumeth.2022.109749

DO - 10.1016/j.jneumeth.2022.109749

M3 - Journal article

C2 - 36414103

VL - 384

JO - Journal of Neuroscience Methods

JF - Journal of Neuroscience Methods

SN - 0165-0270

M1 - 109749

ER -

ID: 333702659