TY - JOUR

T1 - Biodiscoveries within the Australian plant genus Eremophila based on international and interdisciplinary collaboration: results and perspectives on outstanding ethical dilemmas

AU - Semple, Susan

AU - Stærk, Dan

AU - Buirchell, Bevan

AU - Fowler, Rachael

AU - Gericke, Oliver

AU - Kjaerulff, Louise

AU - Zhao, Yong

AU - Pedersen, Hans Albert

AU - Petersen, Malene Johanne

AU - Rasmussen, Line Fentz

AU - Bredahl, Emilie Kold

AU - Pedersen, Gustav Blichfeldt

AU - McNair, Laura M.

AU - Ndi, Chi

AU - Hansen, Nikolaj Lervad

AU - Heskes, Allison

AU - Bayly, Mike

AU - Loland, Claus Juul

AU - Heinz, Nanna

AU - Møller, Birger Lindberg

PY - 2022

Y1 - 2022

N2 - In a cross-continental research initiative, including researchers in Australia and Denmark, and based on joint external funding by a 3-year grant from the Novo Nordisk Foundation, we have used DNA sequencing, extensive chemical profiling and molecular networking analyses across the entire Eremophila genus to provide new knowledge on the presence of natural products and their bioactivities using polypharmocological screens. Sesquiterpenoids, diterpenoids and dimers of branched-chain fatty acids with previously unknown chemical structures were identified. The collection of plant material from the Eremophila genus was carried out according to a 'bioprospecting agreement' with the Government of Western Australia. We recognize that several Eremophila species hold immense cultural significance to Australia's First Peoples. In spite of our best intentions to ensure that new knowledge gained about the genus Eremophila and any potential future benefits are shared in an equitable manner in accordance with the Nagoya protocol, we encounter serious dilemmas and potential conflicts in making benefit sharing with Australia's First Peoples a reality

AB - In a cross-continental research initiative, including researchers in Australia and Denmark, and based on joint external funding by a 3-year grant from the Novo Nordisk Foundation, we have used DNA sequencing, extensive chemical profiling and molecular networking analyses across the entire Eremophila genus to provide new knowledge on the presence of natural products and their bioactivities using polypharmocological screens. Sesquiterpenoids, diterpenoids and dimers of branched-chain fatty acids with previously unknown chemical structures were identified. The collection of plant material from the Eremophila genus was carried out according to a 'bioprospecting agreement' with the Government of Western Australia. We recognize that several Eremophila species hold immense cultural significance to Australia's First Peoples. In spite of our best intentions to ensure that new knowledge gained about the genus Eremophila and any potential future benefits are shared in an equitable manner in accordance with the Nagoya protocol, we encounter serious dilemmas and potential conflicts in making benefit sharing with Australia's First Peoples a reality

U2 - 10.1111/tpj.15866

DO - 10.1111/tpj.15866

M3 - Journal article

C2 - 35696314

VL - 111

SP - 936

EP - 953

JO - Plant Journal

JF - Plant Journal

SN - 0960-7412

IS - 4

M1 - 15866

ER -