Chronic oral nicotine increases brain [3H]epibatidine binding and responsiveness to antidepressant drugs, but not nicotine, in the mouse forced swim test
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
Chronic oral nicotine increases brain [3H]epibatidine binding and responsiveness to antidepressant drugs, but not nicotine, in the mouse forced swim test. / Andreasen T., Jesper; Nielsen, Elsebet O; Redrobe, John P.
I: Psychopharmacology, Bind 205, Nr. 3, 01.08.2009, s. 517-28.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Chronic oral nicotine increases brain [3H]epibatidine binding and responsiveness to antidepressant drugs, but not nicotine, in the mouse forced swim test
AU - Andreasen T., Jesper
AU - Nielsen, Elsebet O
AU - Redrobe, John P
PY - 2009/8/1
Y1 - 2009/8/1
N2 - Smoking rates among depressed individuals is higher than among healthy subjects, and nicotine alleviates depressive symptoms. Nicotine increases serotonergic and noradrenergic neuronal activity and facilitates serotonin and noradrenaline release. In mice, acute nicotine administration enhances the activity of antidepressants in the mouse forced swim (mFST) and tail suspension tests. Here, we investigated if this action of nicotine is also reflected in a chronic treatment regimen.
AB - Smoking rates among depressed individuals is higher than among healthy subjects, and nicotine alleviates depressive symptoms. Nicotine increases serotonergic and noradrenergic neuronal activity and facilitates serotonin and noradrenaline release. In mice, acute nicotine administration enhances the activity of antidepressants in the mouse forced swim (mFST) and tail suspension tests. Here, we investigated if this action of nicotine is also reflected in a chronic treatment regimen.
KW - Animals
KW - Antidepressive Agents
KW - Behavior, Animal
KW - Bicyclo Compounds, Heterocyclic
KW - Binding Sites
KW - Brain
KW - Disease Models, Animal
KW - Dose-Response Relationship, Drug
KW - Female
KW - Mice
KW - Mice, Inbred Strains
KW - Motor Activity
KW - Nicotine
KW - Nicotinic Agonists
KW - Norepinephrine
KW - Pyridines
KW - Radioligand Assay
KW - Receptors, Nicotinic
KW - Serotonin
KW - Stress, Psychological
U2 - 10.1007/s00213-009-1560-1
DO - 10.1007/s00213-009-1560-1
M3 - Journal article
C2 - 19452140
VL - 205
SP - 517
EP - 528
JO - Psychopharmacology
JF - Psychopharmacology
SN - 0033-3158
IS - 3
ER -
ID: 34329132