Cognitive deficits in the rat chronic mild stress model for depression: relation to anhedonic-like responses

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Cognitive deficits in the rat chronic mild stress model for depression: relation to anhedonic-like responses. / Henningsen, Kim; Andreasen T., Jesper; Bouzinova, Elena V.; Jayatissa, Magdalena Niepsuj; Jensen, Morten S; Redrobe, John P; Wiborg, Ove.

I: Behavioural Brain Research, Bind 198, Nr. 1, 02.03.2009, s. 136-41.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Henningsen, K, Andreasen T., J, Bouzinova, EV, Jayatissa, MN, Jensen, MS, Redrobe, JP & Wiborg, O 2009, 'Cognitive deficits in the rat chronic mild stress model for depression: relation to anhedonic-like responses', Behavioural Brain Research, bind 198, nr. 1, s. 136-41. https://doi.org/10.1016/j.bbr.2008.10.039

APA

Henningsen, K., Andreasen T., J., Bouzinova, E. V., Jayatissa, M. N., Jensen, M. S., Redrobe, J. P., & Wiborg, O. (2009). Cognitive deficits in the rat chronic mild stress model for depression: relation to anhedonic-like responses. Behavioural Brain Research, 198(1), 136-41. https://doi.org/10.1016/j.bbr.2008.10.039

Vancouver

Henningsen K, Andreasen T. J, Bouzinova EV, Jayatissa MN, Jensen MS, Redrobe JP o.a. Cognitive deficits in the rat chronic mild stress model for depression: relation to anhedonic-like responses. Behavioural Brain Research. 2009 mar. 2;198(1):136-41. https://doi.org/10.1016/j.bbr.2008.10.039

Author

Henningsen, Kim ; Andreasen T., Jesper ; Bouzinova, Elena V. ; Jayatissa, Magdalena Niepsuj ; Jensen, Morten S ; Redrobe, John P ; Wiborg, Ove. / Cognitive deficits in the rat chronic mild stress model for depression: relation to anhedonic-like responses. I: Behavioural Brain Research. 2009 ; Bind 198, Nr. 1. s. 136-41.

Bibtex

@article{1cb836b6e480470abc56c0b3125da9da,
title = "Cognitive deficits in the rat chronic mild stress model for depression: relation to anhedonic-like responses",
abstract = "The chronic mild stress (CMS) protocol is widely used to evoke depressive-like behaviours in laboratory rats. The aim of the present study was to examine the effects of chronic stress on cognitive performance. About 70% of rats exposed to 7 weeks of chronic mild stress showed a gradual reduction in consumption of a sucrose solution, indicating an anhedonic-like state. The remaining rats did not reduce their sucrose intake, but appeared resilient to the stress-induced effects on sucrose intake. Cognitive profiling of the CMS rats revealed that chronic stress had a negative effect on performance in the spontaneous alternation test, possibly reflecting a deficit in working memory. This effect was independent of whether the stressed rats were anhedonic-like or stress-resilient as measured by their sucrose intake. CMS did not influence performance in passive avoidance and auditory cued fear conditioning, however, in rats displaying an anhedonic-like profile, CMS increased freezing behaviour in contextual fear conditioning.",
keywords = "Acoustic Stimulation, Analysis of Variance, Animals, Avoidance Learning, Body Weight, Cognition, Conditioning, Classical, Cues, Depression, Disease Models, Animal, Exploratory Behavior, Fear, Feeding Behavior, Freezing Reaction, Cataleptic, Male, Memory, Movement, Rats, Rats, Wistar, Stress, Physiological, Sucrose",
author = "Kim Henningsen and {Andreasen T.}, Jesper and Bouzinova, {Elena V.} and Jayatissa, {Magdalena Niepsuj} and Jensen, {Morten S} and Redrobe, {John P} and Ove Wiborg",
year = "2009",
month = mar,
day = "2",
doi = "10.1016/j.bbr.2008.10.039",
language = "English",
volume = "198",
pages = "136--41",
journal = "Behavioural Brain Research",
issn = "0166-4328",
publisher = "Elsevier",
number = "1",

}

RIS

TY - JOUR

T1 - Cognitive deficits in the rat chronic mild stress model for depression: relation to anhedonic-like responses

AU - Henningsen, Kim

AU - Andreasen T., Jesper

AU - Bouzinova, Elena V.

AU - Jayatissa, Magdalena Niepsuj

AU - Jensen, Morten S

AU - Redrobe, John P

AU - Wiborg, Ove

PY - 2009/3/2

Y1 - 2009/3/2

N2 - The chronic mild stress (CMS) protocol is widely used to evoke depressive-like behaviours in laboratory rats. The aim of the present study was to examine the effects of chronic stress on cognitive performance. About 70% of rats exposed to 7 weeks of chronic mild stress showed a gradual reduction in consumption of a sucrose solution, indicating an anhedonic-like state. The remaining rats did not reduce their sucrose intake, but appeared resilient to the stress-induced effects on sucrose intake. Cognitive profiling of the CMS rats revealed that chronic stress had a negative effect on performance in the spontaneous alternation test, possibly reflecting a deficit in working memory. This effect was independent of whether the stressed rats were anhedonic-like or stress-resilient as measured by their sucrose intake. CMS did not influence performance in passive avoidance and auditory cued fear conditioning, however, in rats displaying an anhedonic-like profile, CMS increased freezing behaviour in contextual fear conditioning.

AB - The chronic mild stress (CMS) protocol is widely used to evoke depressive-like behaviours in laboratory rats. The aim of the present study was to examine the effects of chronic stress on cognitive performance. About 70% of rats exposed to 7 weeks of chronic mild stress showed a gradual reduction in consumption of a sucrose solution, indicating an anhedonic-like state. The remaining rats did not reduce their sucrose intake, but appeared resilient to the stress-induced effects on sucrose intake. Cognitive profiling of the CMS rats revealed that chronic stress had a negative effect on performance in the spontaneous alternation test, possibly reflecting a deficit in working memory. This effect was independent of whether the stressed rats were anhedonic-like or stress-resilient as measured by their sucrose intake. CMS did not influence performance in passive avoidance and auditory cued fear conditioning, however, in rats displaying an anhedonic-like profile, CMS increased freezing behaviour in contextual fear conditioning.

KW - Acoustic Stimulation

KW - Analysis of Variance

KW - Animals

KW - Avoidance Learning

KW - Body Weight

KW - Cognition

KW - Conditioning, Classical

KW - Cues

KW - Depression

KW - Disease Models, Animal

KW - Exploratory Behavior

KW - Fear

KW - Feeding Behavior

KW - Freezing Reaction, Cataleptic

KW - Male

KW - Memory

KW - Movement

KW - Rats

KW - Rats, Wistar

KW - Stress, Physiological

KW - Sucrose

U2 - 10.1016/j.bbr.2008.10.039

DO - 10.1016/j.bbr.2008.10.039

M3 - Journal article

C2 - 19038290

VL - 198

SP - 136

EP - 141

JO - Behavioural Brain Research

JF - Behavioural Brain Research

SN - 0166-4328

IS - 1

ER -

ID: 34329065