TY - JOUR

T1 - Effects of amphetamine and methylphenidate on attentional performance and impulsivity in the mouse 5-Choice Serial Reaction Time Task

AU - Caballero Puntiverio, Maitane

AU - Fitzpatrick, Ciarán Martin

AU - Woldbye, David Paul Drucker

AU - Andreasen T., Jesper

PY - 2017

Y1 - 2017

N2 - Background: Few studies have investigated the effects of conventional attention deficit-hyperactivity disorder (ADHD) medication in the mouse5-choice serial reaction time task (5-CSRTT), and rat studies have yielded inconsistent results.Objective: We aimed to examine the effects of acute methylphenidate (MPH) and amphetamine (AMPH) treatment in the mouse 5-CSRTT.Methods: Trained male C57Bl/6J mice were tested in a variable stimulus duration schedule. Effects of AMPH (0.25, 0.5, and 1 mg/kg) and MPH (0.5,1.0, and 2.0 mg/kg) on discriminative accuracy, omissions, and premature responses were assessed. Saline treatment data determined high- and lowattentive (LA), and high- and low-impulsive (LI) subgroups according to the upper and lower 30th percentiles, respectively.Results: In the LA subgroup accuracy was improved by 0.5 mg/kg AMPH and 2 mg/kg MPH, while no effect was found in the high-attentive (HA)subgroup. Premature responses were increased by 1 mg/kg AMPH and 0.5 mg/kg MPH for all animals, and by 1 mg/kg AMPH for the LI subgroup.Conclusions: The use of variable stimulus duration, along with the division into high- and LA, and high-and LI subgroups, may improve the sensitivityof the 5-CSRTT when investigating drug effects on attention and impulsivity.

AB - Background: Few studies have investigated the effects of conventional attention deficit-hyperactivity disorder (ADHD) medication in the mouse5-choice serial reaction time task (5-CSRTT), and rat studies have yielded inconsistent results.Objective: We aimed to examine the effects of acute methylphenidate (MPH) and amphetamine (AMPH) treatment in the mouse 5-CSRTT.Methods: Trained male C57Bl/6J mice were tested in a variable stimulus duration schedule. Effects of AMPH (0.25, 0.5, and 1 mg/kg) and MPH (0.5,1.0, and 2.0 mg/kg) on discriminative accuracy, omissions, and premature responses were assessed. Saline treatment data determined high- and lowattentive (LA), and high- and low-impulsive (LI) subgroups according to the upper and lower 30th percentiles, respectively.Results: In the LA subgroup accuracy was improved by 0.5 mg/kg AMPH and 2 mg/kg MPH, while no effect was found in the high-attentive (HA)subgroup. Premature responses were increased by 1 mg/kg AMPH and 0.5 mg/kg MPH for all animals, and by 1 mg/kg AMPH for the LI subgroup.Conclusions: The use of variable stimulus duration, along with the division into high- and LA, and high-and LI subgroups, may improve the sensitivityof the 5-CSRTT when investigating drug effects on attention and impulsivity.

U2 - 10.1177/0269881116684339

DO - 10.1177/0269881116684339

M3 - Journal article

C2 - 28093027

VL - 31

SP - 272

EP - 283

JO - Journal of Psychopharmacology

JF - Journal of Psychopharmacology

SN - 0269-8811

IS - 2

ER -