Leishmanicidal, antiplasmodial and cytotoxic activity of indole alkaloids from Corynanthe pachyceras
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Leishmanicidal, antiplasmodial and cytotoxic activity of indole alkaloids from Corynanthe pachyceras. / Staerk, D; Lemmich, E; Christensen, J; Kharazmi, A; Olsen, C E; Jaroszewski, J W.
I: Planta Medica, Bind 66, 2000, s. 531-536.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Leishmanicidal, antiplasmodial and cytotoxic activity of indole alkaloids from Corynanthe pachyceras
AU - Staerk, D
AU - Lemmich, E
AU - Christensen, J
AU - Kharazmi, A
AU - Olsen, C E
AU - Jaroszewski, J W
N1 - Keywords: Alkaloids; Animals; Antineoplastic Agents, Phytogenic; Antiprotozoal Agents; Humans; Indoles; Leishmania major; Plants, Medicinal; Plasmodium falciparum; Tumor Cells, Cultured
PY - 2000
Y1 - 2000
N2 - Five indole alkaloids, corynantheidine, corynantheine, dihydrocorynantheine, alpha-yohimbine and corynanthine were isolated from bark of Corynanthe pachyceras K. Schum. (Rubiaceae). The structures were established by spectroscopic methods, including previously unreported assignment of all 1H-NMR resonances by COSY and NOESY experiments. These and related alkaloids showed pronounced activity against Leishmania major promastigotes (IC50 at the micromolar level) but no significant in vitro antiplasmodial activity (against chloroquine-sensitive Plasmodium falciparum). Cytotoxicity assessed with drug sensitive KB-3-1 and multidrug-resistant KB-V1 cell lines was low; the alkaloids are apparently not substrates for the P-glycoprotein (P-170) efflux pump.
AB - Five indole alkaloids, corynantheidine, corynantheine, dihydrocorynantheine, alpha-yohimbine and corynanthine were isolated from bark of Corynanthe pachyceras K. Schum. (Rubiaceae). The structures were established by spectroscopic methods, including previously unreported assignment of all 1H-NMR resonances by COSY and NOESY experiments. These and related alkaloids showed pronounced activity against Leishmania major promastigotes (IC50 at the micromolar level) but no significant in vitro antiplasmodial activity (against chloroquine-sensitive Plasmodium falciparum). Cytotoxicity assessed with drug sensitive KB-3-1 and multidrug-resistant KB-V1 cell lines was low; the alkaloids are apparently not substrates for the P-glycoprotein (P-170) efflux pump.
M3 - Journal article
C2 - 10985079
VL - 66
SP - 531
EP - 536
JO - Planta Medica
JF - Planta Medica
SN - 0032-0943
ER -
ID: 18226201