Low maternal care exacerbates adult stress susceptibility in the chronic mild stress rat model of depression

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Standard

Low maternal care exacerbates adult stress susceptibility in the chronic mild stress rat model of depression. / Henningsen, Kim; Dyrvig, Mads; Bouzinova, Elena V; Christiansen, Sofie; Christensen, Trine; Andreasen, Jesper T; Palme, Rupert; Lichota, Jacek; Wiborg, Ove.

I: Behavioural Pharmacology, Bind 23, Nr. 8, 12.2012, s. 735-43.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Henningsen, K, Dyrvig, M, Bouzinova, EV, Christiansen, S, Christensen, T, Andreasen, JT, Palme, R, Lichota, J & Wiborg, O 2012, 'Low maternal care exacerbates adult stress susceptibility in the chronic mild stress rat model of depression', Behavioural Pharmacology, bind 23, nr. 8, s. 735-43. https://doi.org/10.1097/FBP.0b013e32835a5184

APA

Henningsen, K., Dyrvig, M., Bouzinova, E. V., Christiansen, S., Christensen, T., Andreasen, J. T., Palme, R., Lichota, J., & Wiborg, O. (2012). Low maternal care exacerbates adult stress susceptibility in the chronic mild stress rat model of depression. Behavioural Pharmacology, 23(8), 735-43. https://doi.org/10.1097/FBP.0b013e32835a5184

Vancouver

Henningsen K, Dyrvig M, Bouzinova EV, Christiansen S, Christensen T, Andreasen JT o.a. Low maternal care exacerbates adult stress susceptibility in the chronic mild stress rat model of depression. Behavioural Pharmacology. 2012 dec.;23(8):735-43. https://doi.org/10.1097/FBP.0b013e32835a5184

Author

Henningsen, Kim ; Dyrvig, Mads ; Bouzinova, Elena V ; Christiansen, Sofie ; Christensen, Trine ; Andreasen, Jesper T ; Palme, Rupert ; Lichota, Jacek ; Wiborg, Ove. / Low maternal care exacerbates adult stress susceptibility in the chronic mild stress rat model of depression. I: Behavioural Pharmacology. 2012 ; Bind 23, Nr. 8. s. 735-43.

Bibtex

@article{1eb9614fe16048e4b960b87e58a965a5,
title = "Low maternal care exacerbates adult stress susceptibility in the chronic mild stress rat model of depression",
abstract = "In the present study we report the finding that the quality of maternal care, in early life, increased the susceptibility to stress exposure in adulthood, when rats were exposed to the chronic mild stress paradigm. Our results indicate that high, as opposed to low maternal care, predisposed rats to a differential stress-coping ability. Thus rats fostered by low maternal care dams became more prone to adopt a stress-susceptible phenotype developing an anhedonic-like condition. Moreover, low maternal care offspring had lower weight gain and lower locomotion, with no additive effect of stress. Subchronic exposure to chronic mild stress induced an increase in faecal corticosterone metabolites, which was only significant in rats from low maternal care dams. Examination of glucocorticoid receptor exon 17 promoter methylation in unchallenged adult, maternally characterized rats, showed an insignificant tendency towards higher total cytosine methylation in rats from low maternal care dams. Assessment of methylation in the resilient versus anhedonic-like rat phenotypes, revealed only minor differences. Thus, maternal care status seems to be a strong predictor or trait marker for the behavioural phenotype.",
keywords = "Animals, Behavior, Animal, Corticosterone, DNA Methylation, Depression, Disease Models, Animal, Disease Susceptibility, Female, Locomotion, Male, Maternal Behavior, Pregnancy, Promoter Regions, Genetic, Rats, Rats, Wistar, Receptors, Glucocorticoid, Stress, Physiological, Weight Gain",
author = "Kim Henningsen and Mads Dyrvig and Bouzinova, {Elena V} and Sofie Christiansen and Trine Christensen and Andreasen, {Jesper T} and Rupert Palme and Jacek Lichota and Ove Wiborg",
year = "2012",
month = dec,
doi = "10.1097/FBP.0b013e32835a5184",
language = "English",
volume = "23",
pages = "735--43",
journal = "Behavioural Pharmacology",
issn = "0955-8810",
publisher = "Lippincott Williams & Wilkins",
number = "8",

}

RIS

TY - JOUR

T1 - Low maternal care exacerbates adult stress susceptibility in the chronic mild stress rat model of depression

AU - Henningsen, Kim

AU - Dyrvig, Mads

AU - Bouzinova, Elena V

AU - Christiansen, Sofie

AU - Christensen, Trine

AU - Andreasen, Jesper T

AU - Palme, Rupert

AU - Lichota, Jacek

AU - Wiborg, Ove

PY - 2012/12

Y1 - 2012/12

N2 - In the present study we report the finding that the quality of maternal care, in early life, increased the susceptibility to stress exposure in adulthood, when rats were exposed to the chronic mild stress paradigm. Our results indicate that high, as opposed to low maternal care, predisposed rats to a differential stress-coping ability. Thus rats fostered by low maternal care dams became more prone to adopt a stress-susceptible phenotype developing an anhedonic-like condition. Moreover, low maternal care offspring had lower weight gain and lower locomotion, with no additive effect of stress. Subchronic exposure to chronic mild stress induced an increase in faecal corticosterone metabolites, which was only significant in rats from low maternal care dams. Examination of glucocorticoid receptor exon 17 promoter methylation in unchallenged adult, maternally characterized rats, showed an insignificant tendency towards higher total cytosine methylation in rats from low maternal care dams. Assessment of methylation in the resilient versus anhedonic-like rat phenotypes, revealed only minor differences. Thus, maternal care status seems to be a strong predictor or trait marker for the behavioural phenotype.

AB - In the present study we report the finding that the quality of maternal care, in early life, increased the susceptibility to stress exposure in adulthood, when rats were exposed to the chronic mild stress paradigm. Our results indicate that high, as opposed to low maternal care, predisposed rats to a differential stress-coping ability. Thus rats fostered by low maternal care dams became more prone to adopt a stress-susceptible phenotype developing an anhedonic-like condition. Moreover, low maternal care offspring had lower weight gain and lower locomotion, with no additive effect of stress. Subchronic exposure to chronic mild stress induced an increase in faecal corticosterone metabolites, which was only significant in rats from low maternal care dams. Examination of glucocorticoid receptor exon 17 promoter methylation in unchallenged adult, maternally characterized rats, showed an insignificant tendency towards higher total cytosine methylation in rats from low maternal care dams. Assessment of methylation in the resilient versus anhedonic-like rat phenotypes, revealed only minor differences. Thus, maternal care status seems to be a strong predictor or trait marker for the behavioural phenotype.

KW - Animals

KW - Behavior, Animal

KW - Corticosterone

KW - DNA Methylation

KW - Depression

KW - Disease Models, Animal

KW - Disease Susceptibility

KW - Female

KW - Locomotion

KW - Male

KW - Maternal Behavior

KW - Pregnancy

KW - Promoter Regions, Genetic

KW - Rats

KW - Rats, Wistar

KW - Receptors, Glucocorticoid

KW - Stress, Physiological

KW - Weight Gain

U2 - 10.1097/FBP.0b013e32835a5184

DO - 10.1097/FBP.0b013e32835a5184

M3 - Journal article

C2 - 23075705

VL - 23

SP - 735

EP - 743

JO - Behavioural Pharmacology

JF - Behavioural Pharmacology

SN - 0955-8810

IS - 8

ER -

ID: 140627916