Palladium-catalyzed asymmetric allylic alkylation of a-aryl ketones
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Quaternary centers can be created asymmetrically in high enantiomeric excess by the proper choice of ligand and metal cation in the Pd-catalyzed asymmetric allylic alkylation of a-aryl ketones. A broad range of ketone enolates can be tolerated in the reaction, as illustrated by the synthesis of conformationally constrained ß-tetralone in 96% ee (see scheme, DBU = 1,8-diazabicyclo[5.4.0]undec-7-ene).
Originalsprog | Engelsk |
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Tidsskrift | Angewandte Chemie International Edition |
Vol/bind | 41 |
Udgave nummer | 18 |
Sider (fra-til) | 3492-3495 |
Antal sider | 4 |
ISSN | 1433-7851 |
DOI | |
Status | Udgivet - 16 sep. 2002 |
Eksternt udgivet | Ja |
ID: 45438013