Picraviane A and B: Nortriterpenes with limonoid-like skeletons containing a heptanolide E-ring system from Picramnia glazioviana
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Picraviane A and B: Nortriterpenes with limonoid-like skeletons containing a heptanolide E-ring system from Picramnia glazioviana . / Gimenes, Leila; Batista Junior, Joao Marcos; dos Santos Junior, Fernando Martins; Souza, Matheus da Silva; Luna-Dulcey, Liany; Ellena, Javier; Cominetti, Marcia Regina; da Silva, Maria Fatima das Graças Fernandes; Vieira, Paulo Cezar; Fernandes, Joao Bastita; Stærk, Dan.
I: Phytochemistry, Bind 163, 2019, s. 38-45.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Picraviane A and B: Nortriterpenes with limonoid-like skeletons containing a heptanolide E-ring system from Picramnia glazioviana
AU - Gimenes, Leila
AU - Batista Junior, Joao Marcos
AU - dos Santos Junior, Fernando Martins
AU - Souza, Matheus da Silva
AU - Luna-Dulcey, Liany
AU - Ellena, Javier
AU - Cominetti, Marcia Regina
AU - da Silva, Maria Fatima das Graças Fernandes
AU - Vieira, Paulo Cezar
AU - Fernandes, Joao Bastita
AU - Stærk, Dan
PY - 2019
Y1 - 2019
N2 - Two highly oxygenated nortriterpenes, picraviane A and B, were isolated from the ethanolic extract of Picramnia glazioviana Engl. The structures were determined by analysis of HRMS and 2D NMR spectroscopic data. Single-crystal X-ray diffraction data was also obtained for picraviane B. The absolute configuration of both compounds were assigned by comparison of experimental and calculated vibrational and electronic circular dichroism spectroscopy, respectively. Picraviane A showed a moderate cytotoxic activity against the triple negative MDA-MB-231 breast cancer cell line. These compounds represent an undescribed class of natural products with limonoid-like skeletons containing a heptanolide as the E-ring.
AB - Two highly oxygenated nortriterpenes, picraviane A and B, were isolated from the ethanolic extract of Picramnia glazioviana Engl. The structures were determined by analysis of HRMS and 2D NMR spectroscopic data. Single-crystal X-ray diffraction data was also obtained for picraviane B. The absolute configuration of both compounds were assigned by comparison of experimental and calculated vibrational and electronic circular dichroism spectroscopy, respectively. Picraviane A showed a moderate cytotoxic activity against the triple negative MDA-MB-231 breast cancer cell line. These compounds represent an undescribed class of natural products with limonoid-like skeletons containing a heptanolide as the E-ring.
U2 - 10.1016/j.phytochem.2019.03.024
DO - 10.1016/j.phytochem.2019.03.024
M3 - Journal article
C2 - 31003042
VL - 163
SP - 38
EP - 45
JO - Phytochemistry
JF - Phytochemistry
SN - 0031-9422
ER -
ID: 215346621