Secretory phospholipase A2-mediated neuronal cell death involves glutamate ionotropic receptors
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To define the significance of glutamate ionotropic receptors in sPLA -mediated neuronal cell death we used the NMDA receptor antagonist MK-801 and the AMPA receptor antagonist PNQX. In primary neuronal cell cultures both MK-801 and PNQX inhibited sPLA - and glutamate-induced neuronal death. [ H]Arachidonic acid release induced by both sPLA and glutamate was partially blocked by MK-801, indicating that the glutamate-NMDA-cPLA pathway contributes to sPLA -induced arachidonic acid release. Systemic administration of MK-801 to rats that had sPLA injected into the right striatum significantly decreased neuronal cell death. We conclude that glutamatergic synaptic activity modulates sPLA -induced neuronal cell death.
Originalsprog | Engelsk |
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Tidsskrift | NeuroReport |
Vol/bind | 13 |
Udgave nummer | 15 |
Sider (fra-til) | 1963-1966 |
Antal sider | 4 |
ISSN | 0959-4965 |
DOI | |
Status | Udgivet - 28 okt. 2002 |
Eksternt udgivet | Ja |
ID: 128615058