Synthesis of azaphenanthridines via anionic ring closure
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A new and convergent synthesis of azaphenanthridines via an anionic ring closure is reported. Ortho-lithiation/in situ borylation of cyanopyridines produces the corresponding cyanopyridylboronic esters, which undergo a Suzuki-Miyaura cross-coupling to give the key intermediates. Addition of lithium morpholide produces the azaphenanthridines.
Originalsprog | Engelsk |
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Tidsskrift | Tetrahedron |
Vol/bind | 61 |
Udgave nummer | 42 |
Sider (fra-til) | 9955-9960 |
Antal sider | 6 |
ISSN | 0040-4020 |
DOI | |
Status | Udgivet - 17 okt. 2005 |
ID: 45437443