The selective 5-HT2A receptor agonist 25CN-NBOH does not affect reversal learning in mice

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

The selective 5-HT2A receptor agonist 25CN-NBOH does not affect reversal learning in mice. / Odland, Anna U.; Kristensen, Jesper L.; Andreasen, Jesper T.

I: Behavioural Pharmacology, Bind 32, Nr. 5, 2021, s. 448-452.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Odland, AU, Kristensen, JL & Andreasen, JT 2021, 'The selective 5-HT2A receptor agonist 25CN-NBOH does not affect reversal learning in mice', Behavioural Pharmacology, bind 32, nr. 5, s. 448-452. https://doi.org/10.1097/FBP.0000000000000626

APA

Odland, A. U., Kristensen, J. L., & Andreasen, J. T. (2021). The selective 5-HT2A receptor agonist 25CN-NBOH does not affect reversal learning in mice. Behavioural Pharmacology, 32(5), 448-452. https://doi.org/10.1097/FBP.0000000000000626

Vancouver

Odland AU, Kristensen JL, Andreasen JT. The selective 5-HT2A receptor agonist 25CN-NBOH does not affect reversal learning in mice. Behavioural Pharmacology. 2021;32(5):448-452. https://doi.org/10.1097/FBP.0000000000000626

Author

Odland, Anna U. ; Kristensen, Jesper L. ; Andreasen, Jesper T. / The selective 5-HT2A receptor agonist 25CN-NBOH does not affect reversal learning in mice. I: Behavioural Pharmacology. 2021 ; Bind 32, Nr. 5. s. 448-452.

Bibtex

@article{6c36c3e535eb4bb6bcb18e723570e83e,
title = "The selective 5-HT2A receptor agonist 25CN-NBOH does not affect reversal learning in mice",
abstract = "Psychedelic 5-hydroxytryptamine 2A receptor (5-HT2AR) agonists are showing promise in the treatment of psychiatric disorders, such as treatment-resistant depression and anxiety. Human studies suggest that enhanced cognitive flexibility may contribute to their clinical efficacy. Both improvement and impairment of cognitive flexibility has been reported with 5-HT2AR ligands, making the link between 5-HT2AR pharmacology and cognitive flexibility equivocal. We tested the selective 5-HT2AR agonist 25CN-NBOH in healthy male C57BL/6JOlaHsd mice in a touchscreen-based mouse reversal learning test. No effects were observed on acquisition of the new stimulus-reward contingency, learning errors, or perseverative responses during reversal. Our results suggest that 25CN-NBOH does not affect reversal learning in the schedule used in this study.",
keywords = "25CN-NBOH, cognitive flexibility, 5-HT2A receptor, psychedelic, reversal learning, serotonin",
author = "Odland, {Anna U.} and Kristensen, {Jesper L.} and Andreasen, {Jesper T.}",
year = "2021",
doi = "10.1097/FBP.0000000000000626",
language = "English",
volume = "32",
pages = "448--452",
journal = "Behavioural Pharmacology",
issn = "0955-8810",
publisher = "Lippincott Williams & Wilkins",
number = "5",

}

RIS

TY - JOUR

T1 - The selective 5-HT2A receptor agonist 25CN-NBOH does not affect reversal learning in mice

AU - Odland, Anna U.

AU - Kristensen, Jesper L.

AU - Andreasen, Jesper T.

PY - 2021

Y1 - 2021

N2 - Psychedelic 5-hydroxytryptamine 2A receptor (5-HT2AR) agonists are showing promise in the treatment of psychiatric disorders, such as treatment-resistant depression and anxiety. Human studies suggest that enhanced cognitive flexibility may contribute to their clinical efficacy. Both improvement and impairment of cognitive flexibility has been reported with 5-HT2AR ligands, making the link between 5-HT2AR pharmacology and cognitive flexibility equivocal. We tested the selective 5-HT2AR agonist 25CN-NBOH in healthy male C57BL/6JOlaHsd mice in a touchscreen-based mouse reversal learning test. No effects were observed on acquisition of the new stimulus-reward contingency, learning errors, or perseverative responses during reversal. Our results suggest that 25CN-NBOH does not affect reversal learning in the schedule used in this study.

AB - Psychedelic 5-hydroxytryptamine 2A receptor (5-HT2AR) agonists are showing promise in the treatment of psychiatric disorders, such as treatment-resistant depression and anxiety. Human studies suggest that enhanced cognitive flexibility may contribute to their clinical efficacy. Both improvement and impairment of cognitive flexibility has been reported with 5-HT2AR ligands, making the link between 5-HT2AR pharmacology and cognitive flexibility equivocal. We tested the selective 5-HT2AR agonist 25CN-NBOH in healthy male C57BL/6JOlaHsd mice in a touchscreen-based mouse reversal learning test. No effects were observed on acquisition of the new stimulus-reward contingency, learning errors, or perseverative responses during reversal. Our results suggest that 25CN-NBOH does not affect reversal learning in the schedule used in this study.

KW - 25CN-NBOH

KW - cognitive flexibility

KW - 5-HT2A receptor

KW - psychedelic

KW - reversal learning

KW - serotonin

U2 - 10.1097/FBP.0000000000000626

DO - 10.1097/FBP.0000000000000626

M3 - Journal article

C2 - 33595957

VL - 32

SP - 448

EP - 452

JO - Behavioural Pharmacology

JF - Behavioural Pharmacology

SN - 0955-8810

IS - 5

ER -

ID: 275429179