Using stable isotope tracing to unravel the metabolic components of neurodegeneration: Focus on neuron-glia metabolic interactions
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Disrupted brain metabolism is a critical component of several neurodegenerative diseases. Energy metabolism of both neurons and astrocytes is closely connected to neurotransmitter recycling via the glutamate/GABA-glutamine cycle. Neurons and astrocytes hereby work in close metabolic collaboration which is essential to sustain neurotransmission. Elucidating the mechanistic involvement of altered brain metabolism in disease progression has been aided by the advance of techniques to monitor cellular metabolism, in particular by mapping metabolism of substrates containing stable isotopes, a technique known as isotope tracing. Here we review key aspects of isotope tracing including advantages, drawbacks and applications to different cerebral preparations. In addition, we narrate how isotope tracing has facilitated the discovery of central metabolic features in neurodegeneration with a focus on the metabolic cooperation between neurons and astrocytes.
Originalsprog | Engelsk |
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Artikelnummer | 106145 |
Tidsskrift | Neurobiology of Disease |
Vol/bind | 182 |
Antal sider | 12 |
ISSN | 0969-9961 |
DOI | |
Status | Udgivet - 2023 |
Bibliografisk note
Funding Information:
The Lundbeck Foundation (grant reference R389-2021-1596 , PhD Fellowship Neuroscience Academy Denmark) is acknowledged for support to EWW . The SSADH Association and the Hørslev Foundation are acknowledged for support to JVA. The Alzheimer-forskningsfonden and the Hørslev Foundation are acknowledged for support to BIA.
Funding Information:
The Lundbeck Foundation (grant reference R389-2021-1596, PhD Fellowship Neuroscience Academy Denmark) is acknowledged for support to EWW. The SSADH Association and the Hørslev Foundation are acknowledged for support to JVA. The Alzheimer-forskningsfonden and the Hørslev Foundation are acknowledged for support to BIA.
Publisher Copyright:
© 2023 The Authors
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