Immune-to-Brain Signaling Effects on the Neural Substrate for Reward: Behavioral Models of Aversion, Anhedonia, and Despair

Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › fagfællebedømt

Standard

Immune-to-Brain Signaling Effects on the Neural Substrate for Reward : Behavioral Models of Aversion, Anhedonia, and Despair. / Klawonn, Anna Mathia; Fritz, Michael.

Neuromethods. Humana Press, 2021. s. 145-167 (Neuromethods, Bind 165).

Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › fagfællebedømt

Harvard

Klawonn, AM & Fritz, M 2021, Immune-to-Brain Signaling Effects on the Neural Substrate for Reward: Behavioral Models of Aversion, Anhedonia, and Despair. i Neuromethods. Humana Press, Neuromethods, bind 165, s. 145-167. https://doi.org/10.1007/978-1-0716-1146-3_7

APA

Klawonn, A. M., & Fritz, M. (2021). Immune-to-Brain Signaling Effects on the Neural Substrate for Reward: Behavioral Models of Aversion, Anhedonia, and Despair. I Neuromethods (s. 145-167). Humana Press. Neuromethods Bind 165 https://doi.org/10.1007/978-1-0716-1146-3_7

Vancouver

Klawonn AM, Fritz M. Immune-to-Brain Signaling Effects on the Neural Substrate for Reward: Behavioral Models of Aversion, Anhedonia, and Despair. I Neuromethods. Humana Press. 2021. s. 145-167. (Neuromethods, Bind 165). https://doi.org/10.1007/978-1-0716-1146-3_7

Author

Klawonn, Anna Mathia ; Fritz, Michael. / Immune-to-Brain Signaling Effects on the Neural Substrate for Reward : Behavioral Models of Aversion, Anhedonia, and Despair. Neuromethods. Humana Press, 2021. s. 145-167 (Neuromethods, Bind 165).

Bibtex

@inbook{56fdea52f90f497cb7a5e7417f128957,
title = "Immune-to-Brain Signaling Effects on the Neural Substrate for Reward: Behavioral Models of Aversion, Anhedonia, and Despair",
abstract = "The role of immune-to-brain signaling in regulating mood and motivational states has received increasing interest, as clinical studies have uncovered a link between systemic inflammation and treatment-resistant major depressive disorder. With these findings, a need for relevant preclinical rodent models has arisen for investigating the role of systemic inflammation and immune-to-brain signaling on motivated behaviors. Here we describe some of the behavioral paradigms currently employed for examining inflammation-induced negative effect and malaise; more specifically we give examples of how the proinflammatory stimulus Escherichia coli lipopolysaccharide (LPS) can be combined with behavioral paradigms for anhedonia, aversion, and despair. We aim to provide the reader with guidance on how to prepare and conduct experiments exploring the effects of LPS induced systemic inflammation on affective behaviors.",
keywords = "Anhedonia, Aversion, Conditioned place aversion, Depression, Despair, Forced swim test, Immune-to-brain signaling, Lipopolysaccharide, Sucrose preference test, Systemic inflammation",
author = "Klawonn, {Anna Mathia} and Michael Fritz",
note = "Publisher Copyright: {\textcopyright} 2021, Springer Science+Business Media, LLC, part of Springer Nature.",
year = "2021",
doi = "10.1007/978-1-0716-1146-3_7",
language = "English",
isbn = "978-1-0716-1145-6",
series = "Neuromethods",
publisher = "Humana Press",
pages = "145--167",
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address = "United States",

}

RIS

TY - CHAP

T1 - Immune-to-Brain Signaling Effects on the Neural Substrate for Reward

T2 - Behavioral Models of Aversion, Anhedonia, and Despair

AU - Klawonn, Anna Mathia

AU - Fritz, Michael

N1 - Publisher Copyright: © 2021, Springer Science+Business Media, LLC, part of Springer Nature.

PY - 2021

Y1 - 2021

N2 - The role of immune-to-brain signaling in regulating mood and motivational states has received increasing interest, as clinical studies have uncovered a link between systemic inflammation and treatment-resistant major depressive disorder. With these findings, a need for relevant preclinical rodent models has arisen for investigating the role of systemic inflammation and immune-to-brain signaling on motivated behaviors. Here we describe some of the behavioral paradigms currently employed for examining inflammation-induced negative effect and malaise; more specifically we give examples of how the proinflammatory stimulus Escherichia coli lipopolysaccharide (LPS) can be combined with behavioral paradigms for anhedonia, aversion, and despair. We aim to provide the reader with guidance on how to prepare and conduct experiments exploring the effects of LPS induced systemic inflammation on affective behaviors.

AB - The role of immune-to-brain signaling in regulating mood and motivational states has received increasing interest, as clinical studies have uncovered a link between systemic inflammation and treatment-resistant major depressive disorder. With these findings, a need for relevant preclinical rodent models has arisen for investigating the role of systemic inflammation and immune-to-brain signaling on motivated behaviors. Here we describe some of the behavioral paradigms currently employed for examining inflammation-induced negative effect and malaise; more specifically we give examples of how the proinflammatory stimulus Escherichia coli lipopolysaccharide (LPS) can be combined with behavioral paradigms for anhedonia, aversion, and despair. We aim to provide the reader with guidance on how to prepare and conduct experiments exploring the effects of LPS induced systemic inflammation on affective behaviors.

KW - Anhedonia

KW - Aversion

KW - Conditioned place aversion

KW - Depression

KW - Despair

KW - Forced swim test

KW - Immune-to-brain signaling

KW - Lipopolysaccharide

KW - Sucrose preference test

KW - Systemic inflammation

U2 - 10.1007/978-1-0716-1146-3_7

DO - 10.1007/978-1-0716-1146-3_7

M3 - Book chapter

AN - SCOPUS:85097299903

SN - 978-1-0716-1145-6

T3 - Neuromethods

SP - 145

EP - 167

BT - Neuromethods

PB - Humana Press

ER -

ID: 269522038